A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
Journal article
Marsh, Elizabeth K, van den Berg, Maaike C W and May, Robin C 2011. A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. PLos ONE. https://doi.org/10.1371/journal.pone.0016839
| Authors | Marsh, Elizabeth K, van den Berg, Maaike C W and May, Robin C |
|---|---|
| Abstract | Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought. |
| Keywords | Innate Immunity |
| Year | 2011 |
| Journal | PLos ONE |
| Publisher | Public Library of Science |
| ISSN | 1932-6203 |
| Digital Object Identifier (DOI) | https://doi.org/10.1371/journal.pone.0016839 |
| Web address (URL) | http://hdl.handle.net/10545/623839 |
| http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
| hdl:10545/623839 | |
| Publication dates | 02 Mar 2011 |
| Publication process dates | |
| Deposited | 12 Jun 2019, 10:22 |
| Accepted | 03 Jan 2011 |
| Rights | Attribution-NonCommercial-NoDerivs 3.0 United States |
| Contributors | University of Birmingham |
| File | File Access Level Open |
| File | File Access Level Open |
| File | File Access Level Open |
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