A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.

Journal article


Marsh, Elizabeth K, van den Berg, Maaike C W and May, Robin C 2011. A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. PLos ONE. https://doi.org/10.1371/journal.pone.0016839
AuthorsMarsh, Elizabeth K, van den Berg, Maaike C W and May, Robin C
Abstract

Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.

KeywordsInnate Immunity
Year2011
JournalPLos ONE
PublisherPublic Library of Science
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0016839
Web address (URL)http://hdl.handle.net/10545/623839
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
hdl:10545/623839
Publication dates02 Mar 2011
Publication process dates
Deposited12 Jun 2019, 10:22
Accepted03 Jan 2011
Rights

Attribution-NonCommercial-NoDerivs 3.0 United States

ContributorsUniversity of Birmingham
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