Multiscale modelling of fluid and solute transport in soft tissues and microvessels

Journal article


Lu, Yiling and Wang, Wen 2010. Multiscale modelling of fluid and solute transport in soft tissues and microvessels. Journal of Multiscale Modelling. https://doi.org/10.1142/S175697371000028X
AuthorsLu, Yiling and Wang, Wen
Abstract

This study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several hundred nanometers, on the endothelial glycocalyx and its effects on interactions between blood and the vessel wall; to a few micrometers, on movement of blood cells in capillaries and transcapillary exchange; to a few millimetres and centimetres, on extracellular matrix deformation and interstitial fluid movement in soft tissues. Interactions between blood cells and capillary wall are discussed when the sizes of the two are of the same order of magnitude, with the glycocalyx on the endothelial and red cell membranes being considered. Exchange of fluid, solutes, and gases by microvessels are highlighted when capillaries have counter-current arrangements. This anatomical feature exists in a number of tissues and is the key in the renal medulla on the urinary concentrating mechanism. The paper also addresses an important phenomenon on the transport of macromolecules. Concentration polarization of hyaluronan on the synovial lining of joint cavities is presented to demonstrate how the mechanism works in principle and how model predictions agree to experimental observations quantitatively.

KeywordsMicrocirculation; Transport solute and macromolecules; Blood-wall interaction; Transcapillary exchange; Tissue oxygenation
Year2010
JournalJournal of Multiscale Modelling
ISSN1756-9737
1756-9745
Digital Object Identifier (DOI)https://doi.org/10.1142/S175697371000028X
Web address (URL)http://hdl.handle.net/10545/314021
hdl:10545/314021
Publication dates2010
Publication process dates
Deposited13 Mar 2014, 13:50
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ContributorsUniversity of Derby
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