Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels

Journal article


Lu, Yiling, Michel, C. C. and Wang, Wen 2012. Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00006.2012
AuthorsLu, Yiling, Michel, C. C. and Wang, Wen
Abstract

To elucidate the clearance of dissolved inert gas from tissues, we have developed numerical models of gas transport in a cylindrical block of tissue supplied by one or two capillaries. With two capillaries, attention is given to the effects of co-current and counter-current flow on tissue gas clearance. Clearance by counter-current flow is compared with clearance by a single capillary or by two co-currently arranged capillaries. Effects of the blood velocity, solubility, and diffusivity of the gas in the tissue are investigated using parameters with physiological values. It is found that under the conditions investigated, almost identical clearances are achieved by a single capillary as by a co-current pair when the total flow per tissue volume in each unit is the same (i.e., flow velocity in the single capillary is twice that in each co-current vessel). For both co-current and counter-current arrangements, approximate linear relations exist between the tissue gas clearance rate and tissue blood perfusion rate. However, the counter-current arrangement of capillaries results in less-efficient clearance of the inert gas from tissues. Furthermore, this difference in efficiency increases at higher blood flow rates. At a given blood flow, the simple conduction-capacitance model, which has been used to estimate tissue blood perfusion rate from inert gas clearance, underestimates gas clearance rates predicted by the numerical models for single vessel or for two vessels with co-current flow. This difference is accounted for in discussion, which also considers the choice of parameters and possible effects of microvascular architecture on the interpretation of tissue inert gas clearance.

KeywordsBlood perfusion; Conduction-capacitance model; Numerical simulation
Year2012
JournalJournal of Applied Physiology
ISSN8750-7587
1522-1601
Digital Object Identifier (DOI)https://doi.org/10.1152/japplphysiol.00006.2012
Web address (URL)http://hdl.handle.net/10545/313833
hdl:10545/313833
Publication datesMay 2012
Publication process dates
Deposited10 Mar 2014, 16:11
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ContributorsUniversity of Derby
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