Differential qualitative analysis: a pragmatic qualitative methodology to support personalised healthcare research in heterogenous samples

Differential qualitative analysis (DQA) was developed as a pragmatic qualitative health methodology for the exploration of individual differences, behaviours, and needs within heterogeneous samples. Existing qualitative methodologies tend to emphasise the identification of general principles, an approach that can lead to standardised treatment, care, and medicine. DQA emphasises the identification of individual variation, in order to inform personalised healthcare. DQA comprises an accessible three-stage approach: first individual profiles are explored and differentiated into research-relevant subgroups; then each subgroup is analysed, and findings identified; finally, the data is analysed in its entirety and overall and subgroup findings are presented. DQA was developed as a new qualitative approach to: (1) emphasise the identification of person and patient-centered findings; (2) facilitate the analysis of sample heterogeneity, including variation in responses and intervention outcomes; (3) provide a convenient, pragmatic, systematic, and transparent methodology; (4) bridge the qualitative-quantitative divide with a mutually accessible approach. DQA may be particularly relevant for mixed methods research, early-stage interventions, and research exploring personalised and patient-centred care, and integrative medicine.

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