A non-injected opioid analgesia protocol for acute pain crisis in adolescents and adults with sickle cell disease
Journal article
Authors | Telfer, Paul, Bestwick, Jonathan, Elander, James, Osias, Arlene, Khalid, Nosheen, Skene, Imogen, Nzouakou, Ruben, Challands, Joanne, Barroso, Filipa and Kaya, Banu |
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Abstract | Initial management of the acute pain crisis (APC) of sickle cell disease (SCD) is often unsatisfactory, and might be improved by developing a standardised analgesia protocol. Here, we report the first stages in developing a standard oral protocol for adolescents and adults. Initially, we performed a dose finding study to determine the maximal tolerated dose of sublingual fentanyl (MTD SLF) given on arrival in the acute care facility, when combined with repeated doses of oral oxycodone. We used |
Keywords | Sickle; Crisis; Pain; Opioid; VOC; Analgesia |
Year | 2021 |
Journal | British Journal of Pain |
Publisher | Sage |
ISSN | 2049-4645 |
Digital Object Identifier (DOI) | https://doi.org/10.1177/20494637211033814 |
Web address (URL) | http://hdl.handle.net/10545/625922 |
http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
hdl:10545/625922 | |
Publication dates | 02 Aug 2021 |
Publication process dates | |
Deposited | 10 Aug 2021, 07:53 |
Accepted | 25 Jun 2021 |
Rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
Contributors | University of Derby |
File | File Access Level Open |
File | File Access Level Open |
File | File Access Level Open |
https://repository.derby.ac.uk/item/95325/a-non-injected-opioid-analgesia-protocol-for-acute-pain-crisis-in-adolescents-and-adults-with-sickle-cell-disease
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